Use of 18F-AV-1451 tau PET and structural MRI to identify Alzheimer’s disease, cognitive impairment


  • Use of tau positron emission tomography (PET) can diagnose Alzheimer’s disease (AD) with high accuracy but structural MRI provides additional information on clinical decline.

Why this matters

  • Methods for diagnosing AD are lacking; detail on the relationships between tau aggregation, brain atrophy, and cognition offers better understanding of the degree to which these processes are independent and which brain regions are critical for symptom development.