Integrating structural and functional MRI network information improved the prediction of clinical worsening of multiple sclerosis (MS), and even conversion from relapsing remitting MS (RRMS) to secondary progressive MS (SPMS).
Why this matters
Identifying patients with MS who have a more severe disease evolution course is important to guide patient management. There is little evidence that conventional MRI can predict the disease course of MS.
Although conventional MRI is used for MS diagnosis, this study suggests that assessing specific system involvement may be more clinically relevant in predicting clinical worsening of patients with MS than information from global MRI measures.