A brain stimulation protocol to reveal biomarkers of motor cortex changes in Rett syndrome

Takeaway

  • A transcranial magnetic stimulation (TMS) protocol was used to reveal differences in motor cortex excitability and inhibition in people with Rett syndrome, as compared with people with epilepsy and healthy controls.

Why this matters

    This paired pulse TMS protocol could be used in clinical and research settings to measure biomarkers associate with Rett syndrome, and to monitor motor deficit progression and responses to treatment.