A circulating biomarker predicts clinical progression in asymptomatic familial frontotemporal lobar degeneration

Takeaway

  • High circulating levels of neurofilament light chain predict short-term risk of clinical conversion in asymptomatic familial frontotemporal lobar degeneration.

Why this matters

    The Class I evidence provided by this study suggests that plasma neurofilament light chain could be a potential prognostic biomarker in familial frontotemporal lobar degeneration, even in those who are asymptomatic.