A five-gene signature to predict relapse-free survival in multiple sclerosis


  • The five-gene signature may be a reliable tool to assist physicians in predicting relapse-free survival (RFS) in people with multiple sclerosis (pwMS) in clinical settings.

Why this matters

  • Studies have identified numerous differentially expressed genes (DEGs) in pwMS and healthy controls, but their value in predicting relapse risk remains elusive.

  • Identification of a five-gene signature to predict RFS in pwMS has implications for personalized, targeted therapy which may significantly impact patient outcomes; however, further research in larger, more diverse samples is needed for validation.