A genome-wide association study identifies two novel loci linked to anti-NMDAR encephalitis


  • A genome-wide association study of anti-NMDA receptor encephalitis identifies two independent genome-wide significant association signals which contain known functional candidate genes.

Why this matters

    To date, the human leukocyte antigen complex is the only known genetic determinant of antibody-mediated encephalitides. This genome-wide association study identified two novel loci associated with this disease. The findings provide a foundation for further identification of novel genetic determinants which would further our understanding of the underlying pathophysiology of anti-NMDA receptor encephalitis.