A higher grey matter density and persistent pain after total knee arthroplasty

Takeaway

  • The development of persistent pain following total knee arthroplasty (TKA) may be contributed to a higher grey matter density in brain regions involved in central sensitization and pain-related fear.

Why this matters

  • A high proportion of patients (15–40%) who have undergone a TKA experience ongoing pain at six months after surgery.

  • It is thought that different adaptation of the nociceptive system that may occur before or after TKA is a potential factor contributing to the development of persistent pain in these patients.

  • This study provides new evidence for the association of grey matter density in brain regions involved in nociceptive processing with the development of persistent pain after TKA.