Children, particularly boys, with pediatric-onset multiple sclerosis (POMS), had significantly higher body mass index (BMI) compared to non-neurologic controls and healthy controls without POMS.
Why this matters
Between 3–10% of patients with multiple sclerosis experience disease onset in childhood (<18 years of age) and are classified as having POMS.
There is a purported link between childhood obesity and the development of POMS. A plausible biological mechanism could be that a low-grade inflammatory state induced by obesity could result in increased neuroinflammation.
However, studies to date in children of different nationalities have produced conflicting results, and further investigation into the association between overweight and obesity and POMS is warranted.