A meta-analysis evaluating white matter disruption in pediatric traumatic brain injury

Takeaway

  • There is widespread disruption of white matter (WM) microstructural organization associated with pediatric traumatic brain injury (TBI), which occurs from immediately post-injury through chronic presentation, and females may be more vulnerable than males.

Why this matters

    Previous small studies have indicated that young patients with TBI have abnormal WM organization and that there are likely correlations between symptoms and decreased WM organization. This study provides supporting evidence in a larger patient population and suggests that treatment approaches may need to differ for young females with TBI.