Takeaway
In this meta-analysis, 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is shown to be associated with an increased risk for migraine with aura (MA) in Caucasians and total migraine risk in Asians.
Why this matters
The link between MTHFR C677T and A1298C polymorphisms and migraine susceptibility is ambiguous; here, the link between these polymorphisms and migraine subtypes provides further evidence that MA and migraine without aura (MO) are distinct disorders.