A new model reveals the timeline of structural imaging brain changes in premanifest to manifest Huntington disease

Takeaway

  • A novel disease progression model reveals the relative magnitude and timescale of subcortical and cortical atrophy changes in premanifest to manifest Huntington disease.

Why this matters

    Longitudinal measurements of brain atrophy using structural magnetic resonance imaging provide powerful markers of disease progression in neurodegenerative diseases. This novel study applied the Gaussian process progression model to determine longitudinal trajectories of regional structural imaging markers in Huntington disease. The findings suggest that this model can provide improved predictive utility of clinical onset compared with existing technologies, which are relevant to both clinical trials and clinical practice.