A new multiorganism pipeline for the discovery of epilepsy therapeutics

Takeaway

  • A novel multiorganism pipeline approach that improves the probability of molecular target conservation from animals to humans has identified chlorothymol as a new anticonvulsant and potential epilepsy therapeutic.

Why this matters

    One-third of those with epilepsy are drug resistant, and the multiorganism pipeline approach described in this study, which uses simple model organisms for pharmacological and genetic screening prior to validation in mammalian systems, may accelerate early preclinical studies for faster drug discovery.