A novel role for microglia in Parkinson’s Disease pathogenesis

Takeaway

  • Microglia are actively involved in the transmission of α-synuclein in Parkinson’s Disease (PD).

Why this matters

  • In PD pathogenesis, misfolded α-synuclein propagates in a prion-like manner from neuron to neuron and subsequently forms aggregates known as Lewy bodies.

  • It is thought that exosomes secreted from microglia could contribute to α-synuclein propagation; however, evidence for this is lacking.