A previously unidentified angiogenin mutation in Hungarian amyotrophic lateral sclerosis patients

Takeaway

  • The R33W missense mutation of angiogenin (ANG) gene results in decreased ribonucleolytic and nuclear translocation activity in people with amyotrophic lateral sclerosis.

Why this matters ?

  • ANG mutations in ALS vary across people of different ancestry and further large cohort studies are needed to understand their relevance across various ethnicities.