A strong association between Guillain-Barré syndrome and SARS-CoV-2 infection is unlikely


  • Patients with Guillain-Barré syndrome (GBS) that were classified as having had a probable or a confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frequently had a similar sensorimotor phenotype of GBS and a demyelinating subtype.

  • No increase in GBS patient recruitment in the International GBS Outcome Study (IGOS) was found during the pandemic; a possible causative link needs to be determined in a case-control study.

Why this matters

  • During the SARS-CoV-2 pandemic, an increase in the number of GBS cases has been reported; however, the link is unclear.

  • This study identified several disease features in GBS patients with probable or confirmed SARS-CoV-2 infection, which may assist clinicians in treating this patient population.