α-synuclein oligomer accumulation as a potential biomarker for Parkinson’s disease

Takeaway

  • There is an accumulation of α-synuclein oligomers in the peripheral nervous system in those with Parkinson’s disease (PD) that can be detected using a minimally invasive skin biopsy.

Why this matters

    This study indicates that α-synuclein oligomer accumulation, quantified from skin biopsy using a proximity ligation assay score, may be a reliable new biomarker for PD.