A systematic review of the global incidence and prevalence of neuromyelitis optica


  • A systematic review showed that global incidences and prevalence of neuromyelitis optica spectrum disorder (NMOSD) was the highest among African ethnicities.

Why this matters

  • Neuromyelitis optica (NMO)/NMOSD is a rare auto-immune disease of the central nervous system. The discovery of aquaporin-4 (AQP4) water channels to discriminate diagnosis from multiple sclerosis, and the introduction and improvements of cell-based technologies which to test for NMOSD has drastically improved the understanding of the disease. However, the cause of the disease is still unknown.

  • Since 2015, only seven population-based studies were available and reviewed. The results of this study will increase the knowledge on the epidemiology of NMOSD, which will aid in identifying potential risk factors and essential features of disease etiology.