A systematic review to identify biomarkers in primary headache


  • Calcitonin gene-related peptide (CGRP) and serotonin (5-HT) are altered to various extents in different types of migraine and could be used as biomarkers in the future.

Why this matters

  • The identification of signaling molecule profiles in cluster headache (CH) and migraine may be useful as a diagnostic tool and improve our understanding of headache pathophysiology.

  • Previous studies have investigated the role of 5-HT and CGRP in CH and migraine but have not provided conclusive results about their eligibility as biomarkers.