A man with multifocal glioblastoma acquires an aggressive secondary tumor with a gain-of-function TP53 mutation that leads to progressive and invasive malignancy.
Why this matters
This unique case report reveals the complexity of multifocal glioblastomas. The observed tumor-specific features highlight the importance of genomic profiling; characterizing each tumor individually could assist the development of personalized treatment plans through molecularly targeted therapy.
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