A TP53 mutation leads to gain-of-function phenotypes in multifocal glioblastoma


  • A man with multifocal glioblastoma acquires an aggressive secondary tumor with a gain-of-function TP53 mutation that leads to progressive and invasive malignancy.

Why this matters

    This unique case report reveals the complexity of multifocal glioblastomas. The observed tumor-specific features highlight the importance of genomic profiling; characterizing each tumor individually could assist the development of personalized treatment plans through molecularly targeted therapy.