Aberrant hippocampal structure and function in juvenile myoclonic epilepsy and unaffected siblings

Takeaway

  • People with juvenile myoclonic epilepsy (JME) and their unaffected siblings exhibit abnormalities of hippocampal volume, shape and positioning, suggesting an underlying neurodevelopmental mechanism during prenatal development.

Why this matters

    The abnormal hippocampal morphology seen in people with JME and their unaffected siblings, irrespective of disease activity, suggests that a novel endophenotype of JME may exist.