Abnormal cellular localization of RNA binding proteins in multiple sclerosis

Takeaway

  • Polypyrimidine tract-binding (PTB) proteins and transactivation response DNA-binding protein of 43kDa (TDP-43) are abnormally localized in some people with multiple sclerosis (MS).

Why this matters ?

  • The pathogenesis of MS remains poorly understood.

  • Previous studies have confirmed mislocalization of PTB, TDP-43 and fused in sarcoma (FUS) protein in Theiler murine encephalomyelitis virus (TMEV)-infected cells, an experimental model of MS.