Absence of subcerebral projection neurons delays amyotrophic lateral sclerosis onset and progression

Takeaway

  • Lack of subcerebral projection neurons is beneficial in a mouse model of amyotrophic lateral sclerosis, suggesting that major corticofugal tracts play a key role in disease onset and progression.

Why this matters

    Improved understanding of neuronal dysfunction in amyotrophic lateral sclerosis could ultimately lead to new therapeutic targets.