Accelerated epigenetic age is linked to faster cognitive decline in urban-dwelling men

Takeaway

  • Epigenetic age acceleration related to immunosenescence is associated with a faster rate of cognitive decline in men, but not women.

Why this matters

  • These results highlight the role of immune function decline on cognitive decline; targeting epigenetic changes related to immunosenescence could reduce the rate of cognitive decline, particularly in middle-aged men.

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