Acceleration of DNA methylation with age is associated with early-onset Alzheimer’s disease


  • In a family with a unique form of Alzheimer’s disease (AD), DNA methylation (DNAm) age was accelerated by 9 years in the offspring with early-onset AD while it was 6–10 years younger than chronological age in the monozygotic triplets irrespective of AD status (two had late-onset AD).

Why this matters

  • DNAm is linked to ageing, and assessment of DNAm at 353 specific DNA sites generates DNAm age which accurately predicts chronological age.

  • These findings support further studies to assess how DNAm-age acceleration is linked with age at onset of AD.