Actigraphy for screening patients with isolated REM sleep behavior disorder and similar conditions


  • The dichotomy index (I<O), a measure expressing the relationship between nocturnal and diurnal motor activity intensity obtained from actigraphy data, can distinguish patients with isolated REM sleep behavior disorder (iRBD) from healthy controls and those with different conditions with similar features.

Why this matters

  • Studies have shown that iRBD can be a prodromal stage of synucleinopathies developing into Parkinson’s disease, dementia with Lewy bodies or multiple system atrophy.

  • The current diagnostic criteria of iRBD include video-polysomnography (v-PSG), which require lot of time and resources, and screening questionnaires, which have limited validity; actigraphy could be an alternative to circumvent those limitations.