Acute sleep loss linked to altered diurnal plasma dynamics of dementia biomarkers in young men

Takeaway

  • Acute sleep loss in healthy young men is linked to altered diurnal plasma dynamics of total tau, a key pathogenic biomarker of Alzheimer’s disease.

Why this matters

    Disrupted sleep is common, particularly among shift workers, and had been linked to Alzheimer’s disease. The elevated plasma total tau levels following sleep loss suggest that disrupted sleep may harm brain health even in young people.