Adenosine deaminase deficiency in people with amyotrophic lateral sclerosis

Takeaway

  • The reduction of astrocyte adenosine deaminase (ADA) increases motor neuron toxicity and could contribute to disease progression in people with amyotrophic lateral sclerosis (ALS).

Why this matters ?

  • ADA modulation, including supplementation with inosine, could represent a novel therapeutic approach to slow disease progression in ALS.