Age and genetic risk for dementia alter brain structure and biomarkers in cognitively normal people

Takeaway

  • Changes in brain structure and biomarkers in cognitively unimpaired individuals differ according to age and APOE ε4 allele status.

Why this matters

    Studying cognitively unimpaired APOE ε4 homozygotes before the age of 70 could elucidate the pathophysiological mechanisms underlying the predisposition to Alzheimer’s disease, and, after the age of 70 years, the mechanisms involved in resistance to the disease.