Alterations in brain metabolites are linked to cognitive impairment in adults living with HIV

Takeaway

  • Distorted metabolites during early HIV infection are mainly limited to basal ganglia and combination antiretroviral therapy is effective in reducing neuroinflammation.

Why this matters

    Magnetic resonance spectroscopy enables non-invasive analysis of metabolite alterations linked to pathological processes in conditions such as HIV. These novel findings could lead to the development of agents that target N-acetyl aspartate signal pathways, reducing neuroinflammation, which could ultimately lessen cognitive impairment in people with HIV.