Early changes in cerebrospinal fluid (CSF) amyloid-β (Aβ) occur in preclinical Alzheimer’s disease (AD), with changes in neuronal injury and neurodegeneration markers possibly occurring closer in time to cognitive decline.
Why this matters
Multiple studies show evidence that the neuropathological course of AD is long and dynamic, with some changes occurring prior to clinical or cognitive symptom onset and some after; however, the sequence of these changes has not been explored in detail.
The incidence of AD is growing at a much faster rate versus available reliable treatments; therefore, a better understanding of the order of changes in AD may contribute to the development of specific therapeutic agents targeting different stages of the disease.
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