Alzheimer’s disease pathophysiological subtypes and treatment implications

Takeaway

  • Three different Alzheimer’s disease (AD) pathophysiological subtypes were proteomically defined that were associated with distinct biological processes - hyperplasticity, innate immune activation, and blood-brain barrier (BBB) dysfunction – and they may respond differently to different types of treatment.

Why this matters

    Understanding whether subtypes of AD are present and respond differently to different medications will improve treatment outcomes.