Alzheimer’s disease prediction in a Chinese genome-wide association study

Takeaway

  • The effectiveness of the models used for Alzheimer’s disease (AD) risk prediction in a genetically susceptible Chinese population confirm the association of identified variants with disease pathogenesis.

Why this matters

  • Genome-wide association studies (GWAS) have identified numerous susceptibility loci for sporadic AD, but few have been validated in longitudinal cohorts; as such, producing predictive models of AD based on selected variants is clinically important to verify or negate any pathologic influence, and to provide disease risk screening tools.

  • The clinical application of these models may be beneficial for AD risk assessment in genetically susceptible individuals of all ages, enabling early management implementation; however, further GWAS in other large cohorts are required for validation.