Amino acid metabolism in episodic and chronic cluster headache


  • A literature review suggests that tyrosine (TYR), tryptophan (TRP), and arginine (ARG) metabolism is dysregulated in those with chronic or episodic cluster headache (CH), and that increased norepinephrine level was associated with chronicity.

Why this matters

    Abnormal TYR, TRP, and ARG metabolism may be a biochemical fingerprint of CH; these changes may contribute to chronicity versus episodic CH and also differentiate CH from other primary headaches such as migraine and tension-type headaches.