Amyloid and vascular markers predict long-term functional outcomes in subcortical vascular cognitive impairment


  • In people with subcortical vascular cognitive impairment, a larger white matter hyperintensity volume at baseline predicts mortality, regardless of the occurrence of stroke.

Why this matters

  • Subcortical vascular cognitive impairment is characterized by the presence of cerebral small vessel disease markers, but the effect of vascular and cerebral amyloid angiopathy markers on long-term clinical outcomes is unknown.

  • These novel findings could help clinicians understand the significant influence of amyloid-β and cerebral small vessel disease on functional outcomes in people with subcortical vascular cognitive impairment and predict their prognosis based on initial imaging markers.