Amyloid burden higher in APOE-ε4 carriers than non-carriers in a middle-aged Hispanic population

Takeaway

  • Amyloid burden was higher in apolipoprotein E epsilon 4 (APOE-ε4) carriers than non-carriers, in a group of middle-aged Hispanic people.

Why this matters

    Higher amyloid burden is related to tau potentiation and neurodegeneration – these results highlight differential effects of genotype on dementia risk in this population, informing future work on pathophysiology and treatment targets.