Amyloid-PET and prediction of future cognitive decline and amyloid accumulation

Takeaway

  • A specific amyloid beta-positron emission tomography (Aβ-PET) threshold is predictive of cognitive decline in clinically normal individuals.

Why this matters

  • A major focus of current research and clinical trials is earlier intervention for dementia-related-disorders; and imaging techniques can be useful for classification of both normal and abnormal thresholds of associated proteins such as Aβ.

  • Optimized thresholds of Aβ-PET can help inform future research and clinical trials targeting early Aβ accumulation and cognitive decline associated with neurodegenerative disorders.