Amyloid PET in adults of non-Hispanic Black origin from an asymptomatic Alzheimer’s disease study

Takeaway

  • Reduced amyloid levels are seen in self-identified non-Hispanic Black (NHB) adults who passed initial criteria for the Anti-Amyloid in Asymptomatic Alzheimer’s Disease (A4) study.

Why this matters

  • Progress has been made towards understanding Alzheimer’s disease (AD) pathology in clinically normal (CN) older adults, but studies largely consist of non-Hispanic White (NHW) cohorts; and as such, greater representation of minority populations is required, particularly given that NHB individuals have a greater risk of clinical AD.

  • Apparent race effects on amyloid levels in asymptomatic AD highlights the need for future longitudinal studies comprising cohorts with diverse cultural ancestries to assess race impact on disease progression, and to gain insight on associated disease mechanisms.