Amyloid-ß positivity is linked to defective short-term learning in cognitively normal adults


  • In preclinical Alzheimer’s disease, cognitive dysfunction is more likely to manifest as defective learning than as impairment of any aspect of episodic memory.

Why this matters

    These novel findings suggest that the primary cognitive consequence of amyloid-ß positivity is the inability to gain experience when exposed to new stimuli, even over very short periods. Similar cognitive tasks could be used for short-term cognitive assessment and to measure the efficacy of pharmacological or non-pharmacological interventions.