The APOE-ε4 allele was associated with increased amyloid-β (Aβ) burden in sporadic Alzheimer’s disease (sAD) only, whereas increased education level was associated with reduced Aβ burden in both sporadic and autosomal dominant AD (ADAD).
Why this matters
Amyloid-β deposition is associated with cognitive decline in both sAD and ADAD; however, whether Aβ accumulation is similarly influenced by environmental (e.g. education) and genetic factors in the preclinical phase of these two variants is unclear.
Educational attainment appears protective against Aβ deposition; therefore, future management strategies for people with lower education level at high risk of AD should potentially incorporate learning aspects such as mathematical puzzles, reading or research.