An imaging biomarker for early familial frontotemporal dementia


  • 18F-flortaucipir-positron emission tomography (PET) may be useful as an early biomarker in patients with microtubule-associated protein tau (MAPT) mutations prior to symptom onset.

Why this matters ?

  • Mutations in MAPT are a common cause of familial frontotemporal dementia (FTD).

  • Imaging biomarkers that allow tau detection in patients who carry MAPT mutations prior to symptom onset may help advance the development of disease-modifying therapies for FTD.