An imaging study of naming errors in neurodegenerative diseases

Takeaway

  • Naming errors reflect dysfunction in separate phases of the naming process and are specific markers for discrete patterns of brain involvement in multiple neurodegenerative disorders.

Why this matters

  • Past studies have mainly emphasized language errors in vascular aphasia and primary progressive aphasia (PPA), with no consideration for other neurodegenerative disorders, and very little focus on the neuroanatomical substrates of these impairments.

  • The commonality in underlying mechanisms of naming deficits across multiple neurodegenerative disorders informs about brain regions involved in normal naming; and has implications for potentially ‘training’ these regions in high risk individuals, in addition to targeted therapy development.