Analgesic effect of stimulating the cingulate cortex and insula in central neuropathic pain


  • Transcranial magnetic stimulation (TMS) of the anterior cingulate cortex (ACC) and posterior superior insula (PSI) had no significant analgesic effect in people with central neuropathic pain (CNP) compared with sham-treated people, although there was a significant decrease in anxiety scores in the ACC-stimulated group and an increase in heat pain threshold in the PSI-stimulated group.

Why this matters

  • Despite not clinically significant, effects of stimulation of the ACC and PSI may provide insights into CNP which remains a significant burden on patients.