Analysis of α-synuclein in brain tissue from people with dementia with Lewy bodies

Takeaway

  • Brain levels of α-synuclein obtained from people with dementia with Lewy bodies (DLB) are associated with the degree of Lewy neuropathology.

Why this matters

    Although α-synuclein is thought to be involved in the neurodegeneration associated with synucleinopathies such as DLB, few studies have biochemically analyzed α-synuclein in diseased human brain tissue. The findings could help guide future research into the toxic mechanisms of pathological α-synuclein.