Analysis of long-term progression of multiple sclerosis


  • After 30 years of symptom onset, people with secondary progressive multiple sclerosis (SPMS) are more likely to have disability and a shorter lifespan than people with relapsing remitting multiple sclerosis (RRMS), which can be determined from magnetic resonance imaging (MRI) scans within a year of diagnosis.

Why this matters

  • People with MS can experience a wide variety of disease progression, and proper early treatment can improve long-term disability outcomes.

  • Since MS disease progression can occur over a 20-year period, it is important to understand the longitudinal relationship between early prognostic features and later clinical outcomes.