Analysis of white matter tracts in Parkinson disease with and without psychosis

Takeaway

  • People with Parkinson disease (PD) with psychosis (PD-P) have widespread white matter (WM) tract abnormalities versus those with PD without psychosis (PD-NP).

Why this matters

  • This study provides novel insights into the pathogenic mechanisms of psychosis in PD, which until now has been relatively understudied.

  • Understanding the pathogenesis of psychosis in PD is important to improve outcomes for affected individuals, who have a poorer prognosis including increased mortality.