Anti-IgLON5 disease: HLA and microtubule-associated protein tau H1

Takeaway

  • Anti-IgLON5 disease is strongly associated with distinct HLA Class II molecules supporting primary autoimmune origin; microtubule-associated protein tau (MAPT) H1 haplotype association suggests a potential underlying neurodegenerative process.

Why this matters

  • Anti-IgLON5 disease is a recently identified neurological disorder; these novel findings may aid understanding of the interplay between autoimmune and neurodegenerative processes of the disease.