Anti-SARS-CoV-2 antibodies in the CSF associated with blood-brain barrier dysfunction in COVID-19

Takeaway

  • High-titer anti–severe acute respiratory syndrome coronavirus 2 (anti–SARS-CoV-2) antibodies were found in the cerebrospinal fluid (CSF) of SARS-CoV-2 positive patients with encephalopathy signs or coma, demonstrating blood–brain barrier (BBB) disruption.

Why this matters

    Understanding the BBB disruption associated with coronavirus disease 2019 (COVID-19) may aid in identifying the mechanism of encephalopathies in these patients, thus leading to improved treatment.