ApoE isoforms impact mitochondrial function leading to altered cognitive function in dementia

Takeaway

  • ApoE-ɛ4 downregulates mitochondrial biogenesis, dynamics and its antioxidative stress proteins and is linked to poor cognitive function in Alzheimer’s disease.

Why this matters

    Alterations in these mitochondria-related proteins could be predictive of cognitive decline in ApoE-ɛ4 carriers; they may also represent a novel target for preventative and therapeutic agents in Alzheimer’s disease.