Apoprotein E and amyloid β deposition in patients with subcortical vascular cognitive impairment

Takeaway

  • Decreased amyloid-β (Aβ) clearance may cause increased Aβ in carriers of apoprotein E (ApoE) ε2 with subcortical vascular cognitive impairment (SVCI).

Why this matters

    While the ApoE ε2 allele is known to reduce the risk of Aβ deposition in Alzheimer’s disease, the relationship in SVCI has not been fully explored. Characterization of this association may help provide better treatments to patients and lay the groundwork for the development of personalized medicine.