Approaches to biomarker quantification in Alzheimer’s Disease and their effect on diagnosis


  • The amyloid-beta (A), tau (T) and neurodegeneration (N) (ATN) classification system provides varied results depending on method used to assess biomarkers.

Why this matters

  • The National Institute on Aging and Alzheimer’s Association has proposed a framework suggesting the ATN biomarkers be compiled to a single classification system.

  • It is unknown how ATN testing approaches affect category prevalence or affect the ability of ATN to act as a predictor of cognitive decline.